N - Isopropyl - N ’ - phenyl - p - phenylenediamine ( IPPD ) CAS N ° : 101 - 72 - 4
نویسنده
چکیده
HISTORY: The SIDS Dossier and Testing Plan were reviewed at the 3rd SIDS Review Meeting where the following SIDS Testing Plan was agreed: no testing () testing (x) Testing on developmental toxicity/teratogenicity was underway at the time of the review meeting. The SIDS Initial Assessment Report was discusse d at SIAM 6 in 1997. It was recommended that the report should be re-drafted and presented to a future SIAM. COMMENTS: The SIAR for SIAM 10 has been restructured to emphasise the hazards in line with the refocused SIDS programme. The principal changes to the text concern human health (mutagenicity and developmental toxicity) end points. The exposure estimates for the environment are now in an annex, which includes some additional data on emissions from tyres although the calculations have not been changed. Any further work required for this substance is a post SIDS activity.
منابع مشابه
Positive relationship-intensity of response to p-phenylenediamine on patch testing and cross-reactions with related allergens.
BACKGROUND Hair dye exposure is the most common cause of sensitization to p-phenylenediamine (PPD). Cross-reactions with structurally related allergens occur. OBJECTIVES It is suggested that a stronger patch test reaction (3+ rather than 1+) to PPD (usually tested as 1% petrolatum) is associated with an increased propensity for cross-reactions. In this article we will demonstrate this associa...
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